Evaluation of humoral immune deficiency in Indian patients with bilateral bronchiectasis with no apparent aetiology

Evaluation of humoral immune deficiency in Indian patients with bilateral bronchiectasis with no apparent aetiology

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Background: Infections continue to be the leading aetiology of bronchiectasis in developing countries like India.Among non-infectious cases, the majority will have no identifiable cause despite extensive evaluation.Recently, immunodeficiency has been recognized as an important aetiology, but data on its prevalence remain rather sparse.

Objectives: The objective of this study is to evaluate the prevalence of humoral immunodeficiency in a cohort of adults with bilateral bronchiectasis with no apparent aetiology.Methods: This is the single-site study from Christian Medical College tonic shower cap (Vellore, India) of adults with HRCT-proven non-infectious bronchiectasis.Humoral immunity was assessed through quantitative analysis of immunoglobulins and IgG subclass levels.

Results: Among 158 orange zinger tomato cases, immunoglobulin deficiency was found in 15%.Low IgM was the most predominate finding (7%), followed by common variable immunodeficiency (3%) and low IgA (2.5%).

In addition, IgG subclass deficiency was found in 5%.In 53% of cases, no specific aetiology could be identified.Conclusion: Humoral immune deficiency is present in a significant proportion of patients with non-infectious bronchiectasis.

Routine measurement of serum immunoglobulins should therefore be considered as part of the evaluation.